Catalyst-controlled enantioselective 1,1-arylboration of unactivated olefins

作者:Wang, W (Wang, Wang)[ 1 ] ; Ding, C (Ding, Chao)[ 1 ] ; Yin, GY (Yin, Guoyin)[ 1 ]

NATURE CATALYSIS

卷: 3 期: 11 页: 951-958

DOI: 10.1038/s41929-020-00523-8

出版年:NOV 2020

在线发表日期: OCT 2020

文献类型:Article

摘要

Enantioselective difunctionalization of alkenes constitutes an efficient strategy to assemble complex chiral molecules from simple racemic or achiral starting materials. Here we present an intermolecular nickel-catalysed enantioselective 1,1-arylboration of unactivated terminal alkenes. The high regio- and enantioselectivities of the reactions arise from a judicious choice of the nickel catalyst rather than the incorporation of a directing group. Moreover, excellent regioselectivities can also be obtained from the reactions of allylbenzenes. We also conducted a series of stereospecific downstream transformations for the enantioenriched secondary boronic esters. These examples represent an efficient catalyst-controlled enantioselective 1,1-difunctionalization of unactivated alkenes.

关键词

KeyWords Plus:FUNCTIONALIZATION; ALKENES; DIFUNCTIONALIZATION; ARYLBORATION

作者信息

通讯作者地址:

Wuhan University Wuhan Univ, Inst Adv Studies, Wuhan, Peoples R China.

通讯作者地址: Yin, GY (通讯作者)

Wuhan Univ, Inst Adv Studies, Wuhan, Peoples R China.

地址:

[ 1 ]‎ Wuhan Univ, Inst Adv Studies, Wuhan, Peoples R China

电子邮件地址:yinguoyin@whu.edu.cn