Ni-Catalyzed stereoselective difunctionalization of alkynes

作者:Liu, WF (Liu, Wenfeng)[ 1 ] ; Kong, WQ (Kong, Wangqing)[ 1 ]

ORGANIC CHEMISTRY FRONTIERS

卷: 7 期: 23 页: 3941-3955

DOI: 10.1039/d0qo01097a

出版年: DEC 7 2020

文献类型:Review

摘要

Tri- and tetrasubstituted olefins are widely present in biologically active molecules and functional materials. However, the methods for the stereoselective construction of such moieties are still very limited and extremely challenging. The transition-metal-catalyzed difunctionalization of alkynes is one of the most straightforward and effective choices. In this review, we summarize the progress of the nickel-catalyzed alkyne difunctionalization reaction, with an emphasis on the strategy and control of stereochemistry.

关键词

KeyWords Plus:BOND-FORMING REACTIONS; NICKEL CATALYSIS; EFFICIENT ROUTE; TETRASUBSTITUTED ALKENES; DECARBONYLATIVE ADDITION; FACILE CONSTRUCTION; ALLYLIC ALCOHOLS; CYCLIZATION; ENONES; CYCLOADDITION

作者信息

通讯作者地址:

Wuhan University Wuhan Univ, Inst Adv Studies IAS, Ctr Precis Synth CPS, Wuhan 430072, Hubei, Peoples R China.

通讯作者地址: Kong, WQ (通讯作者)

Wuhan Univ, Inst Adv Studies IAS, Ctr Precis Synth CPS, Wuhan 430072, Hubei, Peoples R China.

地址:

[ 1 ]‎ Wuhan Univ, Inst Adv Studies IAS, Ctr Precis Synth CPS, Wuhan 430072, Hubei, Peoples R China

电子邮件地址:wqkong@whu.edu.cn