周宇

学科专业： 生物信息与功能基因组学

研究方向： 生物信息学、功能基因组学、RNA组学

实验室位置：生科大楼6109，6101室

联系方式： 027-68756749

Email地址: yu.zhou@whu.edu.cn

学习经历：

1999-09~2003-06 武汉大学本科生物学基地班

2003-09~2004-09 武汉大学硕士生化与分子生物学

2004-10~2005-07 法国巴黎十一大学硕士

2005-09~2008-12 武汉大学博士生化与分子生物学

2005-09~2008-12 法国巴黎十一大学博士(与武汉大学联合培养)

主要工作经历与任职情况：

2009-07~2015-05 美国加州大学圣地亚哥分校博士后

2015-05~至今 武汉大学生命科学学院研究员

2015-08~至今 武汉大学高等研究院兼职研究员

主要研究领域及兴趣：

近年来发展起来的不同高通量测序技术（如ChIP-seq、RNA-seq和GRO-seq等），带来了不同层次的定量生物学信息，扩大和加深了研究者对于细胞内基因调控的理解，包括对RNA结合蛋白在基因转录和可变剪接中作用的认识。随着测序成本持续下降，高通量测序技术将常规地用于基础和转化医学研究，这将产生海量的生物学数据，同时也带来了挑战。本实验室将建立“干湿混合”的平台，并将专注于生物信息学及RNA系统生物学的研究。主要的工作包含：（1）开发高通量测序数据的可视化和分析工具以及异质型数据的整合平台，帮助生物学研究人员提高数据处理加工速度和能力，促进高通量测序数据转换成生物学发现；2）鉴定RNA转录终止和通读的调控机制及其在相关疾病中的作用；3）基于RASL-seq检测平台建立特定疾病的基因表达及可变剪接的特征图谱；4）miRNA的生成加工及功能；5）非编码RNA的结构与功能。同时与其他国内外实验室合作，从生物信息学角度解决多种生物学问题。

代表性论文：

（#共同第一作者，*通讯作者）

1.Lanfeng Wang#,Yu Zhou#, Liang Xu#, Rui Xiao#, Xingyu Lu, Liang Chen, Jenny Chong, Hairi Li, Chuan He, Xiang-Dong Fu & Dong Wang*. Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex.Nature(2015)523, 621–625.

2.Shatakshi Pandit#,Yu Zhou#, Lily Shiue#, Gabriela Coutinho-Mansfield, Hairi Li, Jinsong Qiu, Jie Huang, Gene W. Yeo, Manuel Ares, Jr.* and Xiang-Dong Fu*. Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing.Molecular Cell(2013) 50(2), 223-235.

3.Yuanchao Xue#,Yu Zhou#, Tongbin Wu, Tuo Zhu, Xiong Ji, Young-Soo Kwon, Chao Zhang, Gene Yeo, Douglas L. Black, Hui Sun, Xiang-Dong Fu*, and Yi Zhang*. Genome-wide analysis of PTB RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping.Molecular Cell(2009) 36(6), 996-1006.

4.Yu Zhou#, Chen Lu#, Qi-Jia Wu#, Yu Wang, Zhi-Tao Sun, Jia-Cong Deng, and Yi Zhang*. GISSD: Group I Intron Sequence and Structure Database.Nucleic Acids Research(2008) 36, D31-D37.

5.Yu Zhou, Hai-Ri Li, Jie Huang, Ge Jin, and Xiang-Dong Fu*. Multiplex analysis of polyA-linked sequences (MAPS): an RNA-seq strategy to profile poly(A+) RNA.Methods Mol Biol(2014) 1125:169-78.

6.Yu Zhou#, Yann Ponty#, Stephane Vialette, Jerome Waldispuhl, Yi Zhang, and Alain Denise*. Flexible RNA design under structure and sequence constraints using formal languages.Proceedings of ACM Conference on Bioinformatics, Computational Biology and Biomedical Informatics(2013).

7.Chaoliang Wei, Jinsong Qiu,Yu Zhou, Yuanchao Xue, Jing Hu, Kunfu Ouyang, Indroneal Banerjee, Caimei Zhang, Biyi Chen, Hairi Li, Ju Chen, Long-Sheng Song, Xiang-Dong Fu*. Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure.Cell Reports(2015) 10: 1521-1533.

8.Nova Fong#, Hyunmin Kim#,Yu Zhou, Xiong Ji, Jinsong Qiu, Tassa Saldi, Katrina Diener, Ken Jones, Xiang-Dong Fu, and David L. Bentley*. Pre-mRNA Splicing is Facilitated by an Optimal RNA Polymerase II Elongation Rate.Genes & Dev.(2014) 28: 2663-2676.

9.Changwei Shao#, Bo Yang#, Tongbin Wu#, Jie Huang, Peng Tang,Yu Zhou, Jie Zhou, Jinsong Qiu, Li Jiang, Hairi Li, Geng Chen, Hui Sun, Yi Zhang, Alain Denise, Dong-Er Zhang, and Xiang-Dong Fu*. Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome.Nat. Struct. Mol. Biol.(2014) 21, 997-1005.

10.Pingping Wang, Zhihong Zhou, Anchang Hu, Claudio Ponte de Albuquerque,Yu Zhou, Lixin Hong, Emma Sierecki, Masahiko Ajiro, Michael Kruhlak, Curtis Harris, Kunliang Guan, Zhi-Ming Zheng, Alexandra C. Newton, Peiqing Sun, Huilin Zhou, and Xiang-Dong Fu*. Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt. Molecular Cell(2014) 54(3):378-391.

11.Xiaorong Zhang, Xinxin Zuo, Bo Yang, Zongran Li, Yuanchao Xue,Yu Zhou, Jie Huang, Xiaolu Zhao, Jie Zhou, Yun Yan, Huiqiong Zhang, Peipei Guo, Hui Sun, Lin Guo, Yi Zhang,and Xiang-Dong Fu*. MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation.Cell(2014) 158, 607-619.

12.Areum Han, Peter Stoilov, Anthony J. Linares,Yu Zhou, Xiang-Dong Fu, Douglas L. Black*. De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function.PLoS Computational Biology(2014) 10(1), e1003442.

13.Yuanchao Xue, Kunfu Ouyang, Jie Huang,Yu Zhou, Hong Ouyang, Hairi Li, Gang Wang, Qijia Wu, Chaoliang Wei, Yanzhen Bi, Li Jiang, Zhiqiang Cai, Hui Sun, Kang Zhang, Yi Zhang, Ju Chen,Xiang -Dong Fu*. Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits.Cell(2013) 152(1-2), 82-96.

14.Xiong Ji,Yu Zhou, Shatakshi Pandit, Jie Huang, Hairi Li, Charles Y. Lin, Rui Xiao, Christopher B. Burge, Xiang-Dong Fu*. SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.Cell(2013) 153(4), 855-868.

15.Hairi Li, Hongyan Zhou, Dong Wang, Jinsong Qiu,Yu Zhou, Xiangqiang Li, Michael G. Rosenfeld, Sheng Ding*, and Xiang-Dong Fu*. Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery.Proc Natl Acad Sci U S A(2012) 109(12), 4609-4614.

招生招聘：

本实验室主要利用高通量测序技术和生物信息学等手段，研究RNA相关的基因表达调控及参与疾病发生的分子机制。热情欢迎对生物信息学及高通量测序技术有兴趣的学生加入。每年拟接收1-2名本科生，2名硕士生，1-博士生和1名博士后。