Difunctionalization of Alkenes Involving Metal Migration

作者:Li, YQ (Li, Yuqiang)[ 1 ] ; Wu, D (Wu, Dong)[ 1 ] ; Cheng, HG (Cheng, Hong-Gang)[ 2 ] ; Yin, GY (Yin, Guoyin)[ 1 ]

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

卷: 59 期: 21 页: 7990-8003

DOI: 10.1002/anie.201913382

出版年: MAY 18 2020

文献类型:Review

摘要

The direct difunctionalization of alkenes, a cheap and abundant feedstock, represents one of the most attractive strategies for increasing molecular complexity in synthetic organic chemistry. In contrast with the 1,2-difunctionalization of alkenes, recent advances showcase alkene 1,n-difunctionalizations (n not equal 2) involving metal migration is an emerging and rapidly growing area of research. This promising strategy not only opens a novel avenue for future development of alkene transformations, but also significantly expands upon the bond disconnections available in modern organic synthesis. This Minireview summarizes recent progress in the migratory difunctionalization of alkenes, with an emphasis on the driving force for metal migration.

关键词

作者关键词:alkenes; regioselectivities; reaction mechanisms; synthetic methods; transition metals

KeyWords Plus:PD(0)-CATALYZED ENANTIOSELECTIVE 1,1-DIARYLATION; SUBSTITUTION-REACTIONS; NONCONJUGATED DIENES; UNACTIVATED OLEFINS; PHASE-TRANSFER; ARYL IODIDES; FUNCTIONALIZATION; HECK; CATALYSIS; HALIDES

作者信息

通讯作者地址:

Wuhan University Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China.

Wuhan University Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China.

通讯作者地址: Yin, GY (通讯作者)

Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China.

通讯作者地址: Cheng, HG (通讯作者)

Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China.

地址:

[ 1 ]‎ Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China

[ 2 ]‎ Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

电子邮件地址:hgcheng@whu.edu.cn; yinguoyin@whu.edu.cn