Palladium-Catalyzed Electro-oxidative C-H Amination toward the Synthesis of Pyrido[1,2-a]benzimidazoles with Hydrogen Evolution

作者:Duan, ZL (Duan, Zhengli)[ 1 ] ; Zhang, L (Zhang, Lin)[ 3 ] ; Zhang, WX (Zhang, Wenxin)[ 1 ] ; Lu, LJ (Lu, Lijun)[ 1 ] ; Zeng, L (Zeng, Li)[ 1 ] ; Shi, RY (Shi, Renyi)[ 1 ] ; Lei, AW (Lei, Aiwen)[ 1,2,3 ]

ACS CATALYSIS

卷: 10 期: 6 页: 3828-3831

DOI: 10.1021/acscatal.0c00103

出版年: MAR 20 2020

文献类型:Article

摘要

Transition-metal-catalyzed oxidative C- H/N-H coupling reaction is an important method to construct C-N bonds. However, stoichiometric oxidants were usually necessary. Here, we report a palladium-catalyzed electro-oxidative intra-molecular C-H/N-H annulation reaction without an external oxidant or additive. A variety of pyrido[1,2-a]benzimidazoles were constructed by a simple, green, and mild path. Experimental results suggested that Pd(0) could be oxidized on the anode to be recycled.

关键词

作者关键词:C-H amination; electro-oxidization; palladium catalysis; hydrogen evolution; cyclization

KeyWords Plus:FUNCTIONALIZATION; COPPER(II)

作者信息

通讯作者地址:

Wuhan University Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Peoples R China.

Chinese Academy of Sciences Shanghai Institute of Organic Chemistry, CAS Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China.

Jiangxi Normal University Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China.

通讯作者地址: Lei, AW (通讯作者)

Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Peoples R China.

通讯作者地址: Lei, AW (通讯作者)

Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China.

通讯作者地址: Lei, AW (通讯作者)

Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China.

地址:

[ 1 ]‎ Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Peoples R China

[ 2 ]‎ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[ 3 ]‎ Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China

电子邮件地址:aiwenlei@whu.edu.cn