Mn-Catalyzed Electrochemical Radical Cascade Cyclization toward the Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one Derivatives

作者:Yuan, Y (Yuan, Yong)[ 1,2 ] ; Zheng, YF (Zheng, Yongfu)[ 1 ] ; Xu, BZ (Xu, Bizhen)[ 1 ] ; Liao, JP (Liao, Jiapeng)[ 1 ] ; Bu, FX (Bu, Faxiang)[ 2 ] ; Wang, SC (Wang, Shengchun)[ 2 ] ; Hu, JG (Hu, Jian-Guo)[ 1 ] ; Lei, AW (Lei, Aiwen)[ 1,2 ]

ACS CATALYSIS

卷: 10 期: 12 页: 6676-6681

DOI: 10.1021/acscatal.0c01324

出版年: JUN 19 2020

文献类型:Article

摘要

Benzo [4,5] imidazo [2,1-a]isoquinolin-6(5H)- one derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and organic materials. Herein, we develop a Mn-catalyzed electrochemical radical cascade cyclization reaction that uses electricity as the primary energy input to promote the reaction, leading to a series of benzo[4,5]imidazo[2,1-a]- isoquinolin-6(5H)-one derivatives under exogenous-oxidant-free conditions. It is worth noting that this electrochemical method can not only realize the synthesis of benzo 4,5 imidazo[2,1- a]isoquinolin-6(5H)-one derivatives but also provides a new strategy for generating alkyl radicals from alkylboronic acids.

关键词

作者关键词:electrochemistry; radical cascade cyclization; alkylboronic acids; benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one derivatives; hydrogen evolution

KeyWords Plus:C-H ALKYLATION; ANNULATION

作者信息

通讯作者地址:

Jiangxi Normal University Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China.

Wuhan University Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Peoples R China.

通讯作者地址: Lei, AW (通讯作者)

Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China.

通讯作者地址: Lei, AW (通讯作者)

Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Peoples R China.

地址:

[ 1 ]‎ Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China

[ 2 ]‎ Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Peoples R China

电子邮件地址:aiwenlei@whu.edu.cn