Recent Progress in the Consecutive Double Heck Reaction

作者:Ju, BH (Ju, Baihang)[ 1 ] ; Kong, WQ (Kong, Wangqing)[ 1 ]

ASIAN JOURNAL OF ORGANIC CHEMISTRY

卷: 9 期: 8 页: 1154-1161

DOI: 10.1002/ajoc.202000230

出版年: AUG 2020

在线发表日期: JUN 2020

文献类型:Review

摘要

Group website: http://wqkong.whu.edu.cnAlthough the Heck reaction has been discovered for more than 50 years, there remains significant opportunities for chemists to make new discoveries. The traditional Heck reaction is mainly limited to the arylation of alkenes, but the efficient construction of diverse polycyclic scaffolds bearing an alkenyl functional group in one-pot operation by consecutive double Heck cyclization has been scarcely investigated. We therefore summarise the recent progress in Pd- and Ni-catalyzed consecutive double Heck cyclization and highlight the enantioselective transformations and their applications in the total synthesis of natural products with congested quaternary carbon stereocenters.

关键词

作者关键词:Double Heck reaction; Cyclization; Enantioselectivity; Heterocycles; Natural products

KeyWords Plus:CATALYZED POLYENE CYCLIZATIONS; ASYMMETRIC HECK; CASCADE REACTIONS; SCOPARIA-DULCIS; NATURAL-PRODUCT; CARBON CENTERS; ANION CAPTURE; ACID-A; PALLADIUM; DERIVATIVES

作者信息

通讯作者地址:

Wuhan University Wuhan Univ, Inst Adv Studies IAS, Ctr Precis Synth CPS, Wuhan 430072, Peoples R China.

通讯作者地址: Kong, WQ (通讯作者)

Wuhan Univ, Inst Adv Studies IAS, Ctr Precis Synth CPS, Wuhan 430072, Peoples R China.

地址:

[ 1 ]‎ Wuhan Univ, Inst Adv Studies IAS, Ctr Precis Synth CPS, Wuhan 430072, Peoples R China

电子邮件地址:wqkong@whu.edu.cn