Ni-Catalyzed Reductive Antiarylative Cyclization of Alkynones

作者:Zhou, ZJ (Zhou, Zhijun)[ 1 ] ; Liu, WF (Liu, Wenfeng)[ 1 ] ; Kong, WQ (Kong, Wangqing)[ 1 ]

ORGANIC LETTERS

卷: 22 期: 17 页: 6982-6987

DOI: 10.1021/acs.orglett.0c02534

出版年: SEP 4 2020

文献类型:Article

摘要

A new catalyst system for the antiarylative cyclization of alkynones and aryl halides through a reductive cross-coupling strategy is developed. The transformation proceeds smoothly in the absence of organometallic reagents and features high functional group tolerance. This method provides an effective platform to access a wide variety of synthetically useful endocyclic tetrasubstituted allylic alcohols in a stereoselective manner.

关键词

KeyWords Plus:ARYLATIVE CYCLIZATION; COUPLING REACTIONS; STEREOSELECTIVE-SYNTHESIS; ALLYLIC ALCOHOLS; ALKYL-HALIDES; ALDEHYDES; ALKENES; 3-ALKYLIDENEOXINDOLES; CARBOPALLADATION; ISOCYANATES

作者信息

通讯作者地址:

Wuhan University Wuhan Univ, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China.

通讯作者地址: Kong, WQ (通讯作者)

Wuhan Univ, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China.

地址:

[ 1 ]‎ Wuhan Univ, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China

电子邮件地址:wqkong@whu.edu.cn