Yi, H (Yi, Hong)^{[ 1 ]} ; Zhang, GT (Zhang, Guoting)^{[ 1 ]} ; Wang, HM (Wang, Huamin)^{[ 1 ]} ; Huang, ZY (Huang, Zhiyuan)^{[ 1 ]} ; Wang, J (Wang, Jue)^{[ 1 ]} ; Singh, AK (Singh, Atul K.)^{[ 1 ]} ; Lei, AW (Lei, Aiwen)^{[ 1,2 ]}

Research and industrial interest in radical C-H activation/radical cross coupling chemistry has continuously grown over the past few decades. These reactions offer fascinating and unconventional approaches toward connecting molecular fragments with high atom- and step-economy that are often complementary to traditional methods. Success in this area of research was made possible through the development of photocatalysis and first-row transition metal catalysis along with the use of peroxides as radical initiators. This Review provides a brief and concise overview of the current status and latest methodologies using radicals or radical cations as key intermediates produced via radical C-H activation. This Review includes radical addition, radical cascade cyclization, radical/radical cross-coupling, coupling of radicals with M-R groups, and coupling of radical cations with nucleophiles (Nu).

KeyWords Plus:METAL-FREE CONDITIONS; C(SP(3))-H BOND FUNCTIONALIZATION; LIGHT PHOTOREDOX CATALYSIS; TERT-BUTYL HYDROPEROXIDE; ALPHA,ALPHA-DIARYL ALLYLIC ALCOHOLS; FREE OXIDATIVE FUNCTIONALIZATION; ELECTRON-DEFICIENT ALKENES; AROMATIC-SUBSTITUTION BHAS; ALPHA-AMINOALKYL RADICALS; CARBON-CARBON BONDS

通讯作者地址: Lei, AW (通讯作者)

Wuhan Univ, Inst Adv Studies, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.

Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China.

地址:

电子邮件地址:aiwenlei@whu.edu.cn

原文PDF链接：

https://pubs.acs.org/doi/10.1021/acs.chemrev.6b00620