Li, YX (Li, Yuxiu)^{[ 1 ]} ; Wang, K (Wang, Kuai)^{[ 1 ]} ; Ping, YY (Ping, Yuanyuan)^{[ 1 ]} ; Wang, YF (Wang, Yifan)^{[ 1 ]} ; Kong, WQ (Kong, Wangqing)^{[ 1 ]}

The first nickel-catalyzed domino Heck cyclization/Suzuki coupling reaction for the synthesis of 3,3-disubstituted oxindoles bearing quaternary all-carbon centers is reported. A wide range of electrophiles, such as aryl iodides, bromides, triflates, and chlorides, are all compatible with the reaction conditions. Moreover, cheap aryl esters, which undergo catalytic C-O bond cleavage, could also be employed as electrophiles. The approach shows good yields and broad scope, complementing a more practical and sustainable alternative to the conventional palladium-based analogues.

KeyWords Plus:O BOND ACTIVATION; ANION CAPTURE PROCESSES; PHENOL DERIVATIVES; QUATERNARY STEREOCENTERS; CASCADE REACTIONS; ASYMMETRIC HECK; ARYL ESTERS; PALLADIUM; ALKENES; NI

通讯作者地址: Kong, WQ (通讯作者)

Wuhan Univ, Inst Adv Studies, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China.

地址:

电子邮件地址:wqkong@whu.edu.cn

原文PDF链接：

https://pubs.acs.org/doi/10.1021/acs.orglett.7b03713