雷爱文

Prof. Aiwen Lei

Editorial Advisory Board Member of Chemical Reviews

International Advisory Board Member of ChemSusChem

Editorial Board Member of Chemistry – An Asian Journal

Editorial Board Member of Chinese Chemical Letters

Editorial Advisory Board Member of Current Organocatalysis

Education

·Ph. D., Organic Chemistry, July, 2000, Shanghai Institute of Organic Chemistry, Chinese Academy of Science (CAS), China, Supervisor - Prof. Xiyan Lu

·B.S., Chemistry Education, July, 1995, Huaibei Normal University, Huaibei, Anhui Province, P. R. China

Research Interest

·Developing highly selective and efficient transition-metal-catalyzed C-C, and C-heteroatom bond formation in syntheses, e.g. oxidative coupling reactions, C-H bond functionalization

·Small molecule (such as CO, O₂, N₂O, H₂O₂, NH₃, ClO₂, etc.) activation with an emphasis on applying such molecules in efficient synthetic methods

·Mechanistic studies including kinetic and active intermediate studies

Research Experience

·2014.10-now, Vice director of the Institute for Advanced Studies (IAS),Wuhan University

·2005.3 -now, Professor of Wuhan University

·2003.8 -2005.3, Research Associate, Department of Chemistry, Stanford University, US, with Professor James, P. Collman

·2000.8-2003.8, Postdoctoral Fellow, Department of Chemistry, the Pennsylvania State University, US, with Professor Xumu Zhang

·1995.9-2000.7, Graduate Studies, Shanghai Institute of Organic Chemistry, CAS, China (SIOC), with Professor Xiyan Lu

Selected Awards

· Overseas Chinese (Innovative Talents) Contribution Award, 2016

· The National Youth Science and Technology Innovation Talents, 2015

· The Roche Chinese Young Investigator Award, 2015

· Fellow of the Royal Society of Chemistry, FRSC, 2015

· Second-Class Natural Science Award of Liaoning Province, 2014

· Overseas Chinese (Innovative Talents) Contribution Award, 2014

· Youth Chemist Award of the Chinese Chemical Society－Physical OrganicChemistry, 2014

· Committee of the Chinese Physical Organic Chemical Society, 2014

· Chinese Chemistry Society－Royal Society of Chemistry Young ChemistAward, 2014

· Guest Professor, University of Münster, 2013

· Asian Rising Stars (15th ACC Meeting), 2013

· Hubei Province Youth Medal, 2013

· NanKai University Lectureship on Organic Chemistry,2013

· First-Class Natural Science Award of Hubei Province, 2012

· Eli Lilly Scientific Excellence Award in Chemistry, 2011

· Lectureship Award under the New Phase Asian Core Program on Cutting-Edge Organic Chemistry in Asia, Singapore, 2011

· Lectureship Awardee of Asian International Symposium for Outstanding Young Scientists，2011

· Lectureship Award under the New Phase Asian Core Program on Cutting-EdgeOrganic Chemistry in Asia, Japan, 2011

· CAPA (Chinese-American Chemistry & Chemical Biology Professors Association)Distinguished Faculty Award, 2009

· Chinese Chemistry Society－John Wiley Young Chemist Award, 2008

· Royal Society Chemistry Journal Grant, 2008

· Synthesis & Synlett Journal Award, 2008

· Wuxi Pharmtech Biological & Organic Creative Award, 2007

·Publications during independent research

1) Tang, Shan; Liu, Yichang; Gao, Xinlong; Wang, Pan; Huang, Pengfei; Lei, Aiwen. Multimetallic-Catalyzed Oxidative Radical Alkynylation with Termianl Alkynes: A New Strategy for C(sp3)-C(sp) Bond Formation. J. Am. Chem. Soc. 2018, DOI: 10.1021/jacs.8b02745

2)Tang, Shan; Wang, Siyuan; Liu, Yichang; Cong, Hengjiang; Lei, Aiwen. Electrochemical Oxidative C-H Amination of Phenols: Access to Triarylamine Derivatives. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201800240

3)Gao, Xinlong; Wang, Pan; Zeng, Li; Tang, Shan; Lei, Aiwen. Cobalt(II)-Catalyzed Electrooxidative C-H Amination of Arenes with Alkylamines. J. Am. Chem. Soc. 2018, 140, 4195-4199

4)Tang, Shan; Wang, Siyuan; Liu, Yichang; Cong, Hengjiang; Lei, Aiwen. Electrochemical oxidative C-H Amination of Phenols: Access to Triarylamine Derivatives. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201800240

5)Tang, Shan; Wang, Dan; Liu, Yichang; Zeng, Li; Lei, Aiwen. Cobalt-catalyzed electrooxidative C-H/N-H [4+2] annulation with ethylene or ethyne. Nature. Commun. 2018, 9, 789

6)Hu, Xia; Zhang, Guoting; Bu, Faxiang; Lei, Aiwen. Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation. Angew. Chem. Int. Ed. 2018, 57, 1286-1290

7)Tian, Jun; Yang, Dali; Wen, Jianguo; Filatov, Alexander S.; Liu, Yuzi; Lei, Aiwen; Lin, Xiao-Min. A stable rhodium single-site catalyst encapsulated within dendritic mesoporous nanochannels. Nanoscale. 2018, 10, 1047-1055

8)Tang, Shan; Liu, Yichang; Lei, Aiwen. Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation. Chem. 2018, 4, 27-45

9)Zhang Guoting; Lin, Yulin; Luo, Xu; Hu, Xia; Chen, Cong; Lei, Aiwen. Oxidative [4+2] annulation of styrenes with alkynes under external-oxidant-free conditons. Nature. Commun. 2018, 9, 1225

10) Wang, H. M.; Lu, Q. Q.; Chiang, C. W.; Luo, Y.; Zhou, J. F.; Wang, G. Y.; and Lei, A. W.; Markovnikov-Selective Radical Addition of S-Nucleophiles to Terminal Alkynes via Photoredox Process, Angew. Chem. Int. Ed. 2017, 129, 610-614

11) Yi, H.; Niu, L. B.; Song, C. L.; Li, Y. Y.; Dou, B. W.; Singh, A. K.; Lei, A. W.; Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant, Angew. Chem. Int. Ed. 2017, 56, 1120 –1124.

12) Wang, P.; Tang, S.; Huang, P. F.; Lei, A. W.; Electrocatalytic Oxidant-Free Dehydrogenative C-H/S-H Cross-Coupling, Angew. Chem. Int. Ed. 2017, 56, 3009-3013.

13) Niu, L. B.; Yi, H.; Wang, S. C.; Liu, T. Y.; Liu, J. M.; Lei, A. W.; Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles, Nature Commun., 2017, 8, DOI: 10.1038/ncomms14226.

14) Yi, H.; Yang, D. L.; Xin, J.; Qi, X. T.; Lan, Y.; Deng, Y.; Pao, C. W.; Lee, J. F.; Lei, A. W.; Unravelling the hidden link of lithium halides and application in the synthesis of organocuprates, Nature Commun., 2017, 8, DOI: 10.1038/ncomms14794

15) Yi, Hong; Zhang, Guoting; Wang, Huamin; Huang, Zhiyuan; Wang, Jue; Singh, Atul K.; Lei, Aiwen, Recent Advances in Radical C-H Activation/Radical Cross-Coupling. Chem. Rev. 2017, 117, 9016 – 9085.

16) Crabtree, Robert H.; Lei, Aiwen, Introduction: C-H Activation. Chem. Rev. 2017, 117, 8481 – 8482.

17) Liu, Kun; Tang, Shan; Huang, Pengfei; Lei, Aiwen. External oxidant-free electrooxidative [3 + 2] annulation between phenol and indole derivatives. Nature Commun. 2017, 8, 775.

18) Wang, H. M.; Lu, Q. Q.; Qian, C. H.; Liu, C.; Liu, W.; Chen, K.; Lei, A. W., Solvent-Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides. Angew. Chem. Int. Ed., 2016, 55, 1094-1097.

19) Tang, S.; Wang, P.; Li, H.; Lei, A. W., Multimetallic catalyzed radical oxidative C(sp3)–H/C(sp)–H cross-coupling between unactivated alkanes and terminal alkynes, Nature commun. 2016, 7, 11676, DOI:10.1038/ncomms11676

20) Wu Li, Zhengli Duan, Xueye Zhang, Heng Zhang, Mengfan Wang, Ru Jiang, Hongyao Zeng, Chao Liu and Aiwen Lei, From Anilines to Isatins: Palladium-Catalyzed Oxidative C−H Double Carbonylation. Angew. Chem. Int. Ed. 2015, 54, 1893-1896.

21) Jianming Liu, Xin Zhang, Hong Yi, Chao Liu, Ren Liu, Heng Zhang, Kelei Zhuo, and Aiwen Lei. Chloroacetate-Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis. Angew. Chem. Int. Ed. 2015, 54, 1261–1265.

22) Shan Tang, Kun Liu, Chao Liu, and Aiwen Lei, Olefinic C-H functionalization through radical alkenylation. Chem. Soc. Rev. 2015, 44(5), 1070-1082.

23) Ke, J.; Tang, Y. L.; Yi, H.; Li, Y. L.; Cheng, Y. D.; Liu, C.; Lei, A. W., Copper-Catalyzed Radical/Radical C(sp³)-H/P-H Cross-Coupling: α-Phosphorylation of Aryl Ketone O-Acetyloximes. Angew. Chem. Int. Ed., 2015, 54, 6604-6607.

24) Zhang, G. T.; Liu, C.; Yi, H.; Meng, Q. Y.; Bian, C. L.; Chen, H.; Jian, J. X.; Wu, L. Z.; Lei, A. W., External Oxidant-Free Oxidative Cross-Coupling: A Photoredox Cobalt-Catalyzed Aromatic C-H Thiolation for Constructing C-S Bonds. J. Am. Chem. Soc. 2015, 137, 9273–9280.1

25) Tang, S.; Zeng, L.; Liu, Y. C.; Lei, A. W., Zinc-Catalyzed Dehydrogenative Cross-Coupling of Terminal Alkynes with Aldehydes: A Simple Access to Ynones. Angew. Chem. Int. Ed. 2015, 54, 15850 –15853.

26) Liu, C.; Yuan, J. W.; Gao, M.; Tang, S.; Li, W.; Shi, R. Y.; Lei, A. W., Oxidative Coupling between Two Hydrocarbons: An Update of Recent C-H Functionalizations. Chem. Rev., 2015, 115 (22), 12138–12204.

27) Wu, K.; Huang, Z. L.; Qi, X. T.; Li, Y. Z.; Zhang, G. H.; Liu, C.; Yi, H.; Meng, L. K.; Bunel, E. E.; Miller, J. T.; Pao, C. W.; Lee, J. F.; Lan, Y.; Lei, A. W., Copper-Catalyzed Aerobic Oxidative Coupling: From Ketone and Diamine to Pyrazine. Sci. Adv. 2015, Vol. 1, no. 9, e1500656. DOI: 10.1126/sciadv.1500656.

28) Zhou, L. L.; Yi, H.; Zhu, L.; Qi, X. T.; Jiang, H. P.; Liu, C.; Feng, Y. Q.; Lan, Y.; Lei, A. W., Tuning the Reactivity of Radical through a Triplet Diradical Cu(II) Intermediate in Radical Oxidative Cross-Coupling. Sci. Rep. 2015, 5, 15934, doi: 10.1038/srep15934.

29) Zhang, G.H.; Yi, H.; Zhang, G.T.; Deng, Y.; Bai, R.P.; Zhang, H.; Miller, J.T.; Kropf, A.J.; Bunel, E.E.; Lei, A. W., Direct Observation of Reduction of Cu(II) to Cu(I) by Terminal Alkynes. J Am Chem Soc 2014, 136, 924-926

30) Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R. P.; Qi, X. T.; Lan, Y.; Lei, A. W., Visible Light Mediated Decarboxylation / Oxidative Amidation of α-Keto Acids with Amines under Mild Conditions Using O₂. Angew Chem Int Ed 2014, 53, 502

31) Li, W.; Liu, C.; Zhang, H.; Ye, K.Y.; Zhang, G.H.; Zhang, W.Z.; Duan, Z.L.; You, S.L.; Lei, A. W., Palladium-Catalyzed Oxidative Carbonylation of N-allylamines for the synthesis of â-lactams. Angew Chem Int Ed 2014, 53, 2443

32) Wang, L.; Wang, Y.X.; Liu, C.; Lei, A. W., CO/C-H as the Acylative Reagent: A Palladium-Catalyzed Aerobic Oxidative Carbonylative Esterfication of Alcohols. Angew Chem Int Ed 2014, 53, 5657

33) Ruopeng Bai, Guanghui Zhang, Hong Yi, Zhiliang Huang, Xiaotian Qi, Chao Liu, Jeffrey T Miller, Arthur Jeremy Kropf, Emilio E Bunel, Yu Lan, and Aiwen Lei. Cu(II)/Cu(I)-Synergistic Cooperation to Lead the Alkyne C-H Activation. J. Am. Chem. Soc., 2014, 136, 16760–16763.

34) Liu, C.; Liu, D.; Lei, A. W., Recent Advance of Transition-Metal Catalyzed Radical Oxidative Cross-Couplings. Acc. Chem. Res. 2014, 47, 3459−3470.

35) He, C.; Zhang, G. H.; Ke, J.; Zhang, H.; Miller, J. T.; Kropf, A. J.; Lei, A. W., Labile Cu(I)-Catalyst/Spectator Cu(II)-Species in Copper-Catalyzed C-C Coupling Reaction: Operando IR, In situ XANES/EXAFS Evidence and Kinetic Investigations.

J Am Chem Soc 2013, 135, 488

36) Lu, Q. Q.; Zhang, J.; Zhao, G. L.; Qi, Y.; Wang, H. M.; Lei, A. W., Dioxygen-Triggered Oxidative Radical Reaction: Direct Aerobic Difunctionalization of Terminal Alkynes towards β-Keto Sulfones. J Am Chem Soc 2013, 135, 11481

37) Muto, K.; Yamaguchi, J.; Lei, A. W.; Itami, K., Isolation, Structure, and Reactivity of an Arylnickel(II) Pivalate Complex in Catalytic C-H/C-O Biaryl Coupling. J Am Chem Soc 2013, 135, 16384

38) He, C.; Ke, J.; Xu, H.; Lei, A. W., Insights toward the Symbiotic Catalysis Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation. Angew Chem Int Edit 2013, 52, 1527

39) Wang, J.; Liu, C.; Yuan, J. W.; Lei, A. W., Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α, β-unsaturated Ketones. Angew Chem Int Edit 2013, 52, 2256

40) Liu, D.; Liu, C.; Li, H.; Lei, A. W., Direct Funtionalization of Tetrahydrofuran and 1,4-Dioxane: A Nickel-Catalyzed Oxidative Csp3-H Arylation. Angew Chem Int Ed 2013, 52, 4453

41) Gao, M.; He, C.; Chen, H. Y.; Bai, R. P.; Cheng, B.; Lei, A. W., Synthesis of Pyrrole by Click Reaction: Silver-Catalyzed Cycloaddition of Terminal Alkynes with isocyanides. Angew Chem Int Edit 2013, 52, 6958

42) Huang, Z. L.; Jin, L. Q.; Feng, Y.; Peng, P.; Yi, H.; Lei, A. W., Iron-Catalyzed Oxidative Radical Cross-Coupling/Cyclization between Phenol and Olefin. Angew Chem Int Edit 2013, 52, 7151

43) Lu, Q. Q.; Zhang, J.; Wei, F. L.; Qi, Y.; Wang, H. M.; Liu, Z. L.; Lei, A. W., Dioxygen Activation by Sulfinic Acids: Direct Oxysulfonylation of Alkenes Leading to Secondary and Tertiary β-Hydroxysulfones. Angew Chem Int Ed 2013, 52, 7156

44) Meng, L. K.; Zhang, G. H.; Liu, C.; Wu, K.; Lei, A. W., Trifluoromethanesulfonic Acid Catalyzed Synergetic Oxidative/[3+2] Cyclization of Quinones with Olefins. Angew Chem Int Edit 2013, 52, 10195

45) Shi, R. Y.; Zhang, H.; Lu, L. J.; Chen, B. R.; Sha, Y. C.; Liu, C.; Lei, A. W., Palladium/Copper-Catalyzed Oxidative C-H Alkenylation/N-Dealkylative Carbonylation of Tertiary Anilines. Angew Chem Int Edit 2013, 52, 10582

46) Guo, M.; Dong, H.; Li, J.; Cheng, B.; Huang, Y. Q.; Feng, Y. Q.; Lei, A. W., Spectroscopic Observation of Iodosylarene Metalloporphyrin Adducts and Manganese(V)-Oxo Porphyrin Species in a Cytochrome P450 Analogue. Nature communications 2012, 3, 1190, DOI:10.1038/ncomms2196

47) He, C.; Guo, S.; Ke, J.; Hao, J.; Xu, H.; Chen, H. Y.; Lei, A. W., Silver-Mediated Oxidative C-H/C-H Functionalization: A Strategy To Construct Polysubstituted Furans. J Am Chem Soc 2012, 134, 5766

48) Zhang, H.; Shi, R. Y.; Ding, A. X.; Lu, L. J.; Chen, B. R.; Lei, A. W., Transition-metal-free Alkoxycarbonylation of Aryl Halides. Angew Chem Int Edit 2012, 51, 12542

49) Weng, Y.; Cheng, B.; He, C.; Lei, A. W., Rational Design of Pd-Catalyzed Csp-Csp Cross-Coupling Reaction Inspired by Kinetic Studies. Angew Chem Int Edit 2012, 51, 9547

50) Liu, C.; Tang, S.; Zheng, L.; Liu, D.; Zhang, H.; Lei, A. W., Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols. Angew Chem Int Edit 2012, 51, 5662

51) Zhang, H.; Shi, R. Y.; Gan, P.; Liu, C.; Ding, A. X.; Wang, Q. Y.; Lei, A. W., Palladium-Catalyzed Oxidative Double C-H Functionalization/Carbonylation for the Synthesis of Xanthones. Angew Chem Int Edit 2012, 51, 5204

52) Liu, Q.; Wu, P.; Yang, Y. H.; Zeng, Z. Q.; Liu, J.; Yi, H.; Lei, A. W., Room-Temperature Copper-Catalyzed Oxidation of Electron-Deficient Arenes and Heteroarenes Using Air. Angew Chem Int Edit 2012, 51, 4666

53) Liu, C.; Tang, S.; Liu, D.; Yuan, J. W.; Zheng, L. W.; Meng, L. K; Lei, A. W., Nickel-Catalyzed Heck-Type Alkenylation of Secondary and Tertiary a-Carbonyl Alkyl Bromides. Angew Chem Int Edit 2012, 51, 3638

54) Liu, C.; Zhang, H.; Shi, W.; Lei, A. W., Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions. Chem Rev 2011, 111, 1780.

55) Shi, W.; Liu, C.; Lei, A. W., Transition-metal catalyzed oxidative cross-coupling reactions to form C-C bonds involving organometallic reagents as nucleophiles. Chem Soc Rev 2011, 40, 2761.

56) Liu, Q.; Zhang, H.; Lei, A. W., Oxidative Carbonylation Reactions: Organometallic Compounds (R-M) or Hydrocarbons (R-H) as Nucleophiles. Angew Chem Int Edit 2011, 50, 10788.

57) Liu, C.; Wang, J.; Meng, L. K.; Deng, Y.; Li, Y.; Lei, A. W., Palladium-Catalyzed Aerobic Oxidative Direct Esterification of Alcohols. Angew Chem Int Edit 2011, 50, 5144.

58) Liu, C.; Deng, Y.; Wang, J.; Yang, Y. Y.; Tang, S.; Lei, A. W., Palladium-Catalyzed C-C Bond Formation To Construct 1,4-Diketones under Mild Conditions. Angew Chem Int Edit 2011, 50, 7337.

59) Liu, W.; Cao, H.; Zhang, H.; Zhang, H.; Chung, K. H.; He, C. A.; Wang, H. B.; Kwong, F. Y.; Lei, A. W., Organocatalysis in Cross-Coupling: DMEDA-Catalyzed Direct C-H Arylation of Unactivated Benzene. J Am Chem Soc 2010, 132, 16737.

60) Hu, Y. H.; Liu, J.; Lu, Z. X.; Luo, X. C.; Zhang, H.; Lan, Y.; Lei, A. W., Base-Induced Mechanistic Variation in Palladium-Catalyzed Carbonylation of Aryl Iodides. J Am Chem Soc 2010, 132, 3153.

61) Jin, L. Q.; Xin, J.; Huang, Z. L.; He, J.; Lei, A. W., Transmetalation is the Rate-Limiting Step: Quantitative Kinetic Investigation of Nickel-Catalyzed Oxidative Coupling of Arylzinc Reagents. J Am Chem Soc 2010, 132, 9607.

62) He, C. A.; Guo, S.; Huang, L.; Lei, A. W., Copper Catalyzed Arylation/C-C Bond Activation: An Approach toward alpha-Aryl Ketones. J Am Chem Soc 2010, 132, 8273.

63) Chen, M.; Zheng, X. L.; Li, W. Q.; He, J.; Lei, A. W., Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents. J Am Chem Soc 2010, 132, 4101.

64) Liu, W.; Cao, H.; Lei, A. W., Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides. Angew Chem Int Edit 2010, 49, 2004.

65) Liu, Q.; Li, G.; He, J.; Liu, J.; Li, P.; Lei, A. W., Palladium-Catalyzed Aerobic Oxidative Carbonylation of Arylboronate Esters under Mild Conditions. Angew Chem Int Edit 2010, 49, 3371.

66) Duan, H.; Meng, L. K.; Bao, D. H.; Zhang, H.; Li, Y.; Lei, A. W., Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of beta-Hydrogen Atoms. Angew Chem Int Edit 2010, 49, 6387.

Publications before independent research

1) Collman, J. P.; Zeng, L.; Wang, H. J. H.; Lei, A. W.; Brauman, J. I. Eur. J. Org. Chem. 2006, 2707.

2) Shen, Z. M.; Lu, X. Y.; Lei, A. W. Tetrahedron 2006, 62, 9237.

3) He, M.; Lei, A. W.; Zhang, X. M. Tetrahedron Lett. 2005, 46, 1823.

4) Lei, A. W.; Lu, X. Y.; Liu, G. S. Tetrahedron Lett. 2004, 45, 1785.

5) Lei, A. W.; Wu, S. L.; He, M. S.; Zhang, X. M. J. Am. Chem. Soc. 2004, 126, 1626.

6) Lei, A. W.; He, M. S.; Zhang, X. M. J. Am. Chem. Soc. 2003, 125, 11472.

7) Lei, A. W.; He, M. S.; Wu, S. L.; Zhang, X. M. Angew. Chem. Int. Ed. 2002, 41, 3457.

8) Lei, A. W.; Waldkirch, J. P.; He, M. S.; Zhang, X. M. Angew. Chem., Int. Ed. 2002, 41, 4526.

9) Lei, A. W.; Liu, G. S.; Lu, X. Y. J. Org. Chem. 2002, 67, 974.

10) Lei, A. W.; Srivastava, M.; Zhang, X. M. J. Org. Chem. 2002, 67, 1969.

11) Lei, A. W.; He, M. S.; Zhang, X. M. J. Am. Chem. Soc. 2002, 124, 8198.

12) Lei, A. W.; Zhang, X. M. Org. Lett. 2002, 4, 2285.

13) Lei, A. W.; Zhang, X. M. Tetrahedron Lett. 2002, 43, 2525.

14) Lei, A. W.; Lu, X. Y. Org. Lett. 2000, 2, 2699.

15) Wang, Z.; Lu, X. Y.; Lei, A. W.; Zhang, Z. G. J. Org. Chem. 1998, 63, 3806.

Invited Lectures

1) 14^th National Conference on Organometallic Chemistry, Suzhou, 2006, 10, 23

2) Hong Kong University of Science and Technology, Hong Kong, 2007, 2, 1

3) ACS National Meeting for Chicago, 2007, 3, 29

4) Merck, US, 2007, 3, 30

5) ACS Meeting, India, 2007, 4, 13

6) WuXi AppTec, Shanghai, 2007, 8, 17

7) 3^rd Asian Symposium on Advanced Organic Synthesis, Kyoto, 2007, 11, 8

8) 7^th Tateshina Conference on Organic Chemistry, Tateshina, Japan, 2007, 11, 9

9) Shenzhen, 2007, 12, 12

10) 2007 International Symposium on Catalysis and Fine Chemicals, Singapore, 2007, 12, 17

11) University of Illinois, US, 2008, 5, 14

12) Middle Atlantic Regional Meeting, New York, 2008, 5, 17

13) MIT, US, 2008, 5, 21

14) 3^rd International Conference on Cutting-Edge Organic Chemistry in Asia, Hangzhou, 2008, 10, 19

15) 15th National Conference on Organometallic Chemistry, Nanjing, 2008, 10, 23

16) RSC, UK, 2008, 10, 26

17) 6^th Jianghuai symposium on organic chemistry, Huaibei, 2008, 11, 8

18) Nankai University, Tianjin, 2008, 12, 5

19) Keda, 2009, 6, 2

20) The 5th SINO-US Symposium on Organic Chemistry, Lanzhou, 2009, 6, 30

21) 8^th Mainland-Taiwan conference on catalysis, Lanzhou, 2009, 8, 10

22) 1^st Wuhan-Hefei-Nanjing symposium of organic chemistry, Wuhan, 2009, 8, 16

23) 6^th National Conference on Organic Chemistry, Xi’an, 2009, 8, 19

24) Chengdu, 2009, 9, 9

25) University of Valloliode, Spain, 2009, 9, 22

26) Durham University, UK, 2009, 9, 24

27) York University, UK, 2009, 9, 25

28) Leibniz-Institut für Katalyse, German, 2009, 9, 28

29) Lonza Company, Switzerland, 2009, 9, 30

30) Renns University, France, 2009, 10, 5

31) LMU Munich, German, 2009, 10, 7

32) 5^th Sino-Japanese Symposium on Organic Chemistry for Young Scientists, Chengdu, 2009, 10, 10

33) 11^th National Conference on Homogeneous Coordination Catalysis, Changsha, 2009, 10, 17

34) 2^nd Asian Conference on Coordination Chemistry, Nanjing, 2009, 11, 2

35) West Virginal University, USA, 2009, 11, 11

36) GSK, USA, 2009, 11, 17

37) Lonza, Guangzhou, 2009, 12, 9

38) Shanghai Institute of Organic Chemistry, CAS, Shanghai, 2009, 12, 14

39) Huazhong University of Science and Technology, Wuhan, 2010, 5, 12

40) Hunan Normal University, Changcha, 2010, 5, 17

41) 6^th Sino-US Conference of Chemistry Professors, Hangzhou, 2010, 6, 15

42) 11^th Tetrahedron Symposia, Beijing, 2010, 6, 22

43) 2010 Organometallic Chemistry Gordon Research Conference, US, 2010, 7, 11

44) Lanzhou Institute of Chemical Physics, CAS, Lanzhou, 2010, 7, 26

45) 3rd Sino-German Frontiers of Chemistry Symposium, Kloster Seeon, Germany, 2010, 8, 14

46) Dalton Discussion 12: catalytic C-H and C-X bond activation, Keynote Leuture, Durham University, UK, 2010, 9, 13

47) University of Liverpool, Liverpool, UK, 2010, 9, 16

48) Sino-Japan, Tianjin, 2010,9,26

49) 4^th International Forum on Homogeneous Catalysis and The First China-Canada Bilateral Symposium on Catalysis, Kunming, 2010,10,8

50) 2^nd International Symposium on Organic Synthesis and Drug Development, Nanjing, 2010, 10, 16

51) 6^th Bilateral Sino-Australia Organic Chemistry Symposium, Huangshan, 2010,10,19

52) 16^th National Conference on Organometallic Chemistry, Wenzhou 2010, 10, 23

53) 11^th International Symposium for Chinese Organic Chemists and 8th International Symposium for Chinese Inorganic Chemists, Taipei, 2010, 10, 25

54) East China Normal University, Shanghai, 2010, 11, 8

55) Shanghai University, Shanghai, 2010, 11, 8

56) Paris, France 2010,11,15

57) Lausanne 2010,11,23

58) Marseille, France 2010,11,25

59) Guangzhou, 2010,11,30

60) Mini-Symposium of Catalysis in Wuhan University, Wuhan, 2011, 1, 23

61) Shenzhen Graduate School of Peking University, Shenzhen, 2011, 4, 21

62) Hubei University, Wuhan, 2011, 4, 27

63) Jiangxi Normal University, Nanchang, 2011, 5, 3

64) BASF, New Jersey, 2011, 5, 9

65) Rutgers University, Rutgers, 2011, 5, 13

66) Argonne National Laboratory, 2011, 5, 17

67) Peking University, Beijing, 2011, 5, 27

68) School of Pharmaceutical Sciences, Wuhan University, Wuhan, 2011, 6, 7

69) Eli Lilly and Company, Shanghai, 2011, 6, 13

70) King Abdullah University of Science and Technology (KAUST), Saudi Arabia, 2011, 6, 25

71) 7^th Sino-US Sino-US Conference of Chemistry Professors, Guiyang, 2011, 6, 30

72) BIT's 2nd Annual World Congress of Catalytic Asymmetric Synthesis, Beijing, 2011, 8, 9

73) Lanzhou Institute of Chemical Physics, Lanzhou, 2011, 8, 12

74) 1^st Symposium on “New Frontiers in Organic Chemistry：Towards Cleaner, Greener Chemical Processes”, Beijing, 2011, 9, 4

75) IME Boron XIV Conference, Canada, 2011, 9, 13

76) 12^th National Conference of Homogeneous Catalysis, Chengdu, 2011, 10, 10

77) Zhejiang University of Technology, 2011, 10, 18,

78) The 7^th National Conference of Organic Chemistry, Nanjing, 2011, 11, 13

79) 2^nd International Conference on Green & Sustainable Chemistry, Singapore, 2011, 11, 15

80) South-Central University for Nationalities, Wuhan, 2011, 11, 24

81) The 9^th National Conference on Physical Organic Chemistry, Shenzhen, 2011, 12, 3

82) 6th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-6), Asian Core Program (ACP), Hongkong, 2011, 12, 14

83) Jiangxi Normal University, Nanchang, 2011, 12, 20

84) Institute of Chemistry, CAS, Beijing, 2011, 12, 23

85) Technical Institute of Physics and Chemistry, CAS, 2011, 12, 23

86) Zhejiang University, 2012, 12, 27

87) Fujian Institute of Research on the Structure of Matter, 2011, 12, 28

88) 8^th CRC International Symposium on Organometallics & Catalysis, Toronto, 2012, 2, 4

89) JSPS lecture, Nagoya University, Nagoya, 2012, 3, 2

90) JSPS lecture, Gakushuin University, Tokyo, 2012, 3, 5

91) JSPS lecture, Tokyo University of Science, Tokyo, 2012, 3, 6

92) JSPS lecture, Tokyo University, Tokyo, 2012, 3, 8

93) JSPS lecture, Riken, Tokyo, 2012, 3, 9

94) JSPS lecture, Kyoto University (Katsura Campus), Kyoto, 2012, 3, 12

95) JSPS lecture, Kyoto University (Uji Campus), Kyoto, 2012, 3, 13

96) JSPS lecture, Osaka University, Osaka, 2012, 3, 15

97) JSPS lecture, Okayama University, Okayama, 2012, 3, 16

98) JSPS lecture, Institute of olecular Science, Nagoya, 2012, 3, 19

99) University of California, Riverside, 2012, 4, 20

100) Eli Lilly, Indiana, 2012, 5, 15

101) East China Normal University, Shanghai, 2012, 6, 22

102) Renns University, France, 2012, 6, 29

103) 15^th International Congress on Catalysis, Munich, Germany, 2012, 7, 4

104) 10^th National Conference on Organic Synthetic Chemistry, Changchun, 2012, 8, 2

105) Nanjing University, Nanjing, 2012, 9, 22

106) Nanjing Normal University, Nanjing, 2012, 9, 23

107) Jiangxi Normal University, Nanchang, 2012, 11, 13

108) Northwest A&F university, Xi’an, 2012, 11, 27

109) Northwest University, Xi’an, 2012, 11, 28

110) Shaanxi Normal University, Xi’an, 2012, 11, 28

111) Fourth Military Medical University, Xi’an, 2012, 11, 29

112) Hunan University, Changsha, 2012, 12, 1

113) Institute of Chemical Research of Catalonia, Spain, 2012, 12, 17

114) Leibniz-Institut für Katalyse, German, 2012, 12, 19

115) National University of Singapore, Singapore, 2013, 2, 21

116) Nanyang Technological University, Singapore, 2013, 2, 22

117) Central South University, Changsha, 2013, 3, 11

118) Mettler Toledo, Shanghai, 2013, 3, 13

119) Mettler Toledo, Beijing, 2013, 3, 15

120) Lanzhou Institute of Chemical Physics, Lanzhou, 2013, 3, 16

121) Hong Kong Polytechnic University, Hong Kong, 2013, 4, 29

122) City University of Hong Kong, Hong Kong, 2013, 4, 30

123) University of Hong Kong, Hong Kong, 2013, 5, 2

124) Northeastern Normal University, Jilin, 2013, 5, 30

125) South China University of Technology, Guangzhou, 2013, 6, 5

126) Henan Normal University, Xinxiang, 2013, 6, 13

127) The 9th Sino-US Chemistry Professors Conference, Chengdu, 2013, 7, 12

128) The 7^th China-Korea Symposium on Organic Chemistry, Xi’an, 2013, 7, 15

129) OMCOS 17, Fort Collins, 2013, 8, 1

130) The 15^th Asian Chemical Congress, Singapore, 2013, 8, 21

131) 2^nd Canada-China Workshop on Green Chemistry and Catalysis, Canada, 2013, 9, 6

132) The 10^th National Conference on Physical Organic Chemistry, Hefei, 2013, 9, 14

133) The 13^th National Conference on Homogeneous catalysis, 2013, 9, 26

134) Beijing Symposium 2013 on “New Frontiers in Organic Chemistry: New Reagents, New Reactions”, Beijing, 2013, 10,10

135) The 8^th National Organic Chemistry Conference, Chongqing, 2013, 10, 18

136) Illinois Institute of Technology, Chicago, 2013, 11, 4

137) The 11^th Jianghuai Symposium on Organic Chemistry, Huaibei, 2013, 11, 10

138) Tsing Hua University, Beijing, 2013, 11, 15

139) Xiamen University, Xiamen, 2013, 11, 21

140) Nanjing University of Aeronautics and Astronautics, Nanjing, 2013, 11, 22

141) University of Heidelberg, 2013.11.27

142) BASF, Ludwigshafen, 2013.11.28

143) University of Aachen, Aachen, 2013. 11. 29

144) University of Münster, Münster, 2013. 12. 1

145) University of Göttingen, Göttingen, 2013. 12 .2

146) Leibniz-Institut für Katalyse, Rostock,2013.12.10

147) University of Münster, Münster, 2013. 12. 13

148) Leshan Normal University, Leshan, 2013.12.20

149) Nanchang University, Nanchang, 2014, 1, 3

150) National Chung Hsing University, Taichung, 2014, 2, 11

151) National Tsing Hua University, Hsinchu, 2014, 2, 12

152) National Taiwan University, 2014, 2, 14

153) Jiangxi Normal University, Nanchang, 2014, 2, 27

154) Nanchang University, Nanchang, 2014, 2, 28

155) 247 ACS meeting, 2014, 3, 18

156) National Chiao Tung University, Hsinchu, 2014, 5, 15

157) International Conference on Catalysis, Beijing, 2014, 6, 13

158) EuCheMS Conference on Organic Free Radicals, Prague, 2014, 6, 29

159) 2nd International Symposium on C-H bond activation, Rennes, France, 2014.7.2

160) 26th International Conference on Organometallic Chemistry (ICOMC2014), Sapporo，Japan，2014, 7, 17

161) 41st International Conference on Coordination Chemistry, Singapore, 2014, 7, 21

162) 29^th Chinses Chemical Society National Meeting, Beijing, 2014, 8, 4

163) International Conference on Physical Organic Chemistry，Ottawa，Canada, 2014.8.11

164) 18^th national Conference on Organometallic Chemistry, Lanzhou, 2014, 8, 19

165) 8th Asian-European Symposium on Metal-Mediated Efficient Organic Synthesis, Turkey, 2014, 9, 7

166) 2nd International Conference on Global Trends in Chemical Sciences, Hong Kong, 2014, 10, 3

167) 13th International Symposium for Chinese Organic Chemists (ISCOC) and 10th International Symposium for Chinese Inorganic Chemists (ISCIC), Xiamen, 2014, 12, 19

168) ACS Meeting, Japan, 2014, 10, 24

169) University of Incheon, Korea, 2014, 11, 26

170) ISCCHM-KAUST International Symposium, Saudi Arabia, 2015, 02, 01

171) ACS Meeting, Japan, 2015, 02, 23

172) Hokkaido University, Sapporo, Japan, 2015, 2, 27

173) the 5th China & Japan Young Chemists Forum, Japan, 2015, 03, 26

174) Lanzhou Institute of Chemical Physics, Lanzhou, 2015, 05, 22

175) 12th International Symposium “Activation of Dioxygen and Homogeneous Oxidation Catalysis” (ADHOC 2015), Wisconsin, USA, 2015

176) Tongji University, Shanghai, 2015, 6, 21

177) 9^th Chinese Chemical Society - Inorganic Chemistry Symposium, Nanchang University, 2015, 07, 25

178) 9^th Chinese Chemical Society - Organic Chemistry Symposium, Jilin, 2015, 07, 28

179) 2015 IUPAC 48^th General Assembly and 45^th World Chemistry Congress (IUPAC-2015), Korea, 2015, 08, 11

180) Shuangqing Forum, 2015, 09, 06

181) Academia Sinica, Taiwan, 2015, 09, 09

182) National Tsing Hua University, Taiwan, 2015, 09, 11

183) East China University of Science and Technology, Shanghai, 2015, 09, 17

184) 21^st Users' Meeting & Workshops, National Synchrotron Radiation Research Center, Taiwan, 2015, 09, 18

185) 11^th Chinese Chemical Society – Physical Organic Chemistry Symposium, 2015, 09, 17

186) 14^th National Homogenous Catalysis Colloquium, Dalian, 2015, 09, 26

187) Huaqiao University, Xiamen, 2015, 10, 10

188) 12^th Chinese Chemical Society – National Synthetic Organic Chemistry Symposium, Guilin, 2015, 10, 15

189) 3^rd Roche and RSC Chemistry Symposium on Leading Science for Drug Discovery, Shanghai, 2015, 10, 23

190) Hunan University, Changsha, 2015, 11, 1

191) International Conference on Cutting-Edge Organic Chemistry in Asia, Kaohsiung, 2015, 11, 4

192) The 5^th Gan-Bo Chemitry Forum, Nanchang, 2016, 1, 8

193) The 4th Editorial board meeting of Chines Chemical Letters, 2016, 1, 23

194) Sciences Chimiques de Rennes, France, 2016, 2, 20

195) Heidelberg University, Germany, 2016, 2, 21

196) University of Grenoble Alpes, France, 2016, 2, 28

197) University of Toulouse, France, 2016, 3, 1

198) Sino-Sweden Bilateral Conference, 2016, 4, 14

199) Chongqing University, Chongqing, 2016, 4, 28

200) Asia Communications and Photonics Conference, South Korea, 2016, 5, 16

201) Seoul National University, Seoul, South Korea, 2016, 5, 17

202) The 16th International Congress on Catalysis, Lanzhou, 2016, 6, 30

203) 30^th Chinses Chemical Society National Meeting, 2016, 7, 1

204) 27^th International Conference on Organometallic Chemistry (ICOMC 2016), Melbourne, Australia, 2016, 7, 21

205) Mettler Toledo, Hangzhou, 2016, 8, 3

206) 252nd American Chemical Society National Meeting & Exposition, Philadelphia, USA, 2016, 8, 21

207) The 3rd International Conference on Organometallics and Catalysis 2016,Korean, 2016, 8, 28

208) The 18^th Annual Meeting of China Association for Science and Technology, Green Chemistry and Clean Energy Forum, Xi’an, 2016, 9, 24

209) 12^th International Symposium on Organic Free Radicals (ISOFR-12), Shanghai, 2016, 10, 13

210) Shanghai Institute of Organic Chemistry, Shanghai, 2016, 10, 27

211) Zhejiang University of Technology, Zhejiang, 2016, 10, 28

212) Nanjing University, Nanjing, 2016, 11, 3

213) Nanjing Tech University, Nanjing, 2016, 11, 4

214) College of Chemistry and Molecular Sciences, Wuhan University – Department of Chemistry, Southern University of Science and Technology Bilateral Forum, Wuhan, 2016, 11, 9

215) International Symposium on Catalysis and Fine Chemicals (C&FC 2016), Taipei, 2016, 11, 12

216) NSFC-ISF Bilateral Conference, Haifa, 2016, 11, 15

217) Harbin Institute of Technology, Harbin, 2017, 1, 18

218) Technical University of Munich, München, Germany, 2017, 2, 3

219) Ludwig Maximilian University of Munich, Munich, Germany, 2017, 2, 6

220) Technology University of Berlin, Berlin, Germany, 2017, 2, 8

221) University of Würzburg, Würzbrug, Germany, 2017, 2, 10

222) University of Rennes, Rennes, France, 2017, 3, 23

223) University of Paris, Paris, France, 2017, 3, 27

224) Wuxi AppTec Group, Wuhan, 2017, 4, 19

225) Midwest Inorganic Chemistry and Chemical Industry Symposium, Xi’an, 2017, 4, 30

226) National University of Defense Technology, Changsha, 2017, 5, 27

227) The 6^th Grubbs Symposium, Shenzhen, 2017, 5, 29

228) Mettler Toledo, Guizhou, 2017, 6, 6

229) The 13^th Sino-US Chemistry Professors Conference, Rudong, Nantong, 2017, 6, 19

230) The Interdisciplinary Innovative Frontier Forum, Nanchang University, Nanchang, 2017, 6, 30

231) The 2^nd International Conference on Hydrogen Atom Transfer (iCHAT), Rome, Italy, 2017, 7

232) Hunan University, Changsha, 2017, 7, 8

233) Opportunities and Challenges in Synthetic Chemistry – Graduate Student Academic Forum, Shanghai, 2017, 7, 25

234) Harvard University, Massachusetts, United States, 2017, 8, 14

235) Beijing University of Technology, Beijing, 2017, 9,15

236) Tsing Hua University, Beijing, 2017, 10, 13

237) Tomorrow’s Catalysis for Research and Industry – Beilstein Organic Chemistry Symposium, Potsdam, Germany, 2017, 10, 24

238) The 14^th National Organic Synthesis Conference, Huaibei, 2017, 10, 27

239) The 1^st National Organic Radical Chemistry Conference, Suzhou, 2017, 11, 4

240) The 10^th CCS National Organic Chemistry Conference, Shenzhen, 2017, 12, 19

241) Xinjiang Normal University, Ürümqi, 2018, 1, 3

242) Quanzhou Normal University, Quanzhou, 2018, 1, 5

243) Fujian Institute of Research on the Structure of Matter, Fuzhou, 2018, 1, 7

244) Zhejiang University of Technology, Zhejiang, 2018, 1, 18

245) Shanghai Institute of Organic Chemistry, Shanghai, 2018, 1, 29

246) Chuyuan Group, Jingzhou, 2018, 2, 9

247) National Tsing Hua University, Taiwan, 2018, 2, 27

248) Hubei University, Hubei, 2018, 3, 7

249) Kyoto University, Kyoto, Japan, 2018, 3, 11

250) Biotechnology and Chemistry for Green Growth, Awaji, Japan, 2018, 3, 14

251) International Conference on Organic and Polymer Synthesis, Guangzhou, 2018, 4, 7

252) Xiamen University, Xiamen, 2018, 5, 18

253) Nanchang University, Nanchang, 2018, 6,7