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研究生指导教师介绍—胥国勇

作者:     点击:      时间:2018-04-24

胥国勇

教授、博士生导师

 实验室网页

https://www.researchgate.net/lab/Guoyong-Xu-Lab-Translatome-Study-of-Plant-Immunity-Guoyong-Xu

 邮箱

guoyong.xu@whu.edu.cn

 

教育经历

20039月– 20077 南开大学生命科学学院       学士

20079月– 20127 清华大学生命科学学院       博士

 

工作经历

201010月– 20137      清华大学生命科学学院       医药实验班本科辅导员

20127月– 20137 清华大学生命科学学院       博士后

20138月–201712 杜克大学生物系                  博士后

20181月起                            武汉大学高等研究院           教授、博士生导师

 

主要奖励

200510 奖励:    南开大学优秀学生

20105   奖励:    中国教育部第一届学术新人奖

201212 奖励:    清华大学12.9优秀本科生辅导员奖

20191   奖励:《麻省理工科技评论》科技创新青年35

 

主要研究概述

  我们组建了生物技术交叉研究实验室,利用多学科交叉融合研究:蛋白质翻译调控(Translational Control)、植物抗病分子机制(Plant Immunity)和精准作物改良(Precision Agriculture)等。

我们主要研究一个生物学机制:蛋白质翻译调控。在过去20多年里,我们领域对植物免疫反应的分子机制有了深入的了解,但都集中于转录(Transcription)和蛋白质翻译后(Post-translation)水平上的调控,而对翻译(mRNA translation)水平上的调控研究还处于起步阶段。负责人回国前的工作揭示了蛋白质翻译调控对植物建立免疫反应发挥了关键作用,并利用了上游阅读框(uORF)介导的翻译调控机制有效解决了农业生产中抗病性增强与产量受损的矛盾。理论和实践研究两篇文章发表于同一期Nature上(Xu et al., nature22371Xu et al., nature22372)。可观看(http://simplebiologist.com/2017/06/23/plant-defense-disease-resistance/)。目前,我们拟建立基于测序技术的方法,包括RIP-seqRNA-seqRibo-seq来研究新的mRNA调控元件;基于Luciferase的高通量遗传筛选体系来研究控制uORFmRNA元件功能的基因;基于Microscopy的细胞生物学体系来研究PhaseSeparation现象和翻译调控的时空关系;基于理论研究寻找天然和人工合成的翻译调控元件控制植物抗性,实现精准作物改良。

我们关注两个生物学问题(一)、植物产量和抗性之间的平衡:植物生长和免疫应答均高度耗能,导致了产量和抗病增强之间的矛盾。我们将研究植物如何通过翻译调控控制抗病基因的表达,从而达到平衡这两个重要的农艺性状,以获得“和谐农作物”。(二)、抗病与株型之间的关系:病原传播和增殖与植物株型提供的微环境密切相关,我们将研究作物微环境与抗病性状之间的关系,包括引起水稻纹枯病(Ricesheath blight)的腐生真菌Rhizoctonia solan与茎叶营养组织微环境,引起水稻黑粉病(Ricekernelsmut)的活体营养真菌Tilletiahorrida与生殖系统微环境。借此开辟真菌行为学(fungal behaviorology)以及生殖系统抗性(reproductive system immunity)新研究方向。

我们以生物技术为核心,融合三个学科交叉方向:(一)组学与信息技术;(二)微流芯片控制技术;(三)合成化学及合成生物技术,来研究上述一个机制和两个生物学问题。

 

 

Guoyong Xu (Ph.D., Professor)

Email

guoyong.xu@whu.edu.cn

LabPage

https://www.researchgate.net/lab/Guoyong-Xu-Lab-Translatome-Study-of-Plant-Immunity-Guoyong-Xu

 

Education

Sep 2007 – Jul 2012                    Tsinghua University, China    Ph.D.

Sep 2003 – Jul 2007                    Nankai University, China      B.S.

 

Working Experience

Jan 2018 – Now                          Wuhan University, China       Professor

Aug 2013 – Dec 2017                  Duke University, U.S.A.              Postdoc

Jul 2012 – Jul 2013                            Tsinghua University, China    Postdoc

Oct 2010 – Jul 2013                    Tsinghua University, China    College Counselor

 

Research Interests:

OurBiotechnology &Interdisciplinary Research Labis aiming to use interdisciplinary strategy to study ‘Translational Control’, ‘Plant Immunity’ and ‘Precision Agriculture’.

We are focusing onone major mechanism, translational control.In the past 20 years, the community of plant defense have had a clear picture of immune regulation at both transcription and post-translation levels. Our work at Duke reveals thatglobal translational reprogramming is a fundamental layer of immune regulation in plants. UsinguORF-mediated translation mechanism,we have successfullyengineered disease resistant plants without fitness costs. Both papers are published back to back on the same issue of Nature journal (Xu et al., nature22371,Xu et al., nature22372).(Watchhttp://simplebiologist.com/2017/06/23/plant-defense-disease-resistance/).We have setup the following platforms: RNA-related sequencing platform including RIP-seq, RNA-seqand Ribo-seq to discovernovel regulatory RNA elements; Luciferase-based genetic screening platform to find out the trans-actingfactors associated with those RNA elements, such as uORF; and Microscopy-based cell biology platform to study phase separation and thespatiotemporal organization and dynamics of translation. We are aiming to illustrate the significance of translational control during plant-microbe interaction and uncover more natural and synthetic regulatory RNA elements to control defense gene expression for precision agriculture.

We are focusing on two basic biological events. One is ‘Plant Growth-Defense Trade-off’. Both plant growth and immune response are highly energy-consuming and the allocation of energy to immune induction usually compromises plant yield. This is a key question commonly encountered both in the lab condition and in the agricultural practice. We are actively resolving this conflict by dissecting translational control mechanisms of plant immunity and hope to harvest ‘Harmonious Crop Cultivars’ with balanced yield and defense traits. The other event is ‘Crop Architecture-Defense Relationship’. Pathogenproliferationand spread is largely dependent on plant architecture which provides comfortable microenvironment such as high humidity and limited ventilation. We are proposing to studyhow crop microenvironments affect the pathogenesis of necrotrophic (Rice sheath blight; Rhizoctonia solani) and biotrophic (Rice kernel smut; Tilletiahorrida) pathogens, which will advance our understanding offungal behaviorology andreproductive system immunity.

To address those questions, we are actively developing novelBiotechniques with the introduction of different disciplines including Omics andinformation technology, Microfluidic technology, and synthetic chemistry and biology.

 

近期代表性论文*Co-first author

1.         Shanshan Wang*, KeXie*, Guoyong Xu*, Huarui Zhou, Qiang Guo, Jingyi Wu, Zengwei Liao, Na Liu, Yan Wang, Yule Liu: Plant G proteins interact with ER luminal protein receptors to regulate ER retrieval: Signaling between ERD2s and G proteins. Journal of Integrative Plant Biology 03/2018;, DOI:10.1111/jipb.12648

2.         Guoyong Xu*, George H. Greene*, HeejinYoo*, Lijing Liu, Jorge Marqués, Jonathan Motley, Xinnian Dong: Global translational reprogramming is a fundamental layer of immune regulation in plants. Nature 04/17; 545(7655): 487-490., DOI:10.1038/nature22371

3.         Guoyong Xu*, Meng Yuan*, Chaoren Ai, Lijing Liu, Edward Zhuang, SargisKarapetyan, Shiping Wang, Xinnian Dong: uORF-mediated translation allows engineered plant disease resistance without fitness cost. Nature 04/17; 545(7655): 491-494.,DOI:10.1038/nature22372

4.         Guoyong Xu*, Shanshan Wang*, Shaojie Han, KeXie, Yan Wang, Jinlin Li, Yule Liu: Plant Bax Inhibitor-1 interacts with ATG6 to regulate autophagy and programmed cell death. Autophagy 07/2017; 13(7):1161-1175., DOI: 10.1080/15548627.2017.1320633

5.         Guoyong Xu, Yule Liu: Plant ERD2s self-interact and interact with GTPase-activating proteins and ADP-ribosylation factor 1. Plant signaling & behavior 09/2012; 7(9)., DOI:10.4161/psb.21217

6.         Guoyong Xu*, Sizhun Li*, KeXie, Qiang Zhang, Yan Wang, Yang Tang, Dong Liu, Yiguo Hong, Chenyang He, Yule Liu: Plant ERD2-like proteins function as ER luminal protein receptors and participate in programmed cell death during innate immunity. The Plant Journal 05/2012; 72(1):57-69., DOI:10.1111/j.1365-313X.2012.05053.x

7.         Guoyong Xu*, Ning Sui*, Yang Tang, KeXie, Yizhen Lai, Yule Liu: One-step, zero-background ligation-independent cloning intron-containing hairpin RNA constructs for RNAi in plants. New Phytologist 07/2010; 187(1):240-50., DOI:10.1111/j.1469-8137.2010.03253.x

 

本科生、研究生:本实验室追求知识的多样性,热忱欢迎具有不同背景的本科生、研究生加入。