武汉大学生命科学学院研究员，博导

研究方向：单分子生物学

招生计划：在高研院每年招生1人，在生科院每年招生2-3人，诚挚邀请博士后加盟

联系方式：Email：zhxh@whu.edu.cn

学习经历

2000.09-2004.07 山东大学物理学院 学士 物理学基地班

2004.09-2009.07 中国科学院物理研究所 博士 软物质物理与生物物理

工作经历

2009.08-2010.03：专利审查员 国家知识产权局

2010.03-2015.10：研究科学家 新加坡-MIT联合科研中心生物系统与微观力学实验室

2015.11-至今 ：  研究员、博导 武汉大学生命科学学院，武汉大学高等研究院

主要研究领域及兴趣

我们主要使用单分子磁镊技术、单分子FRET技术，在单分子水平上研究生物大分子结构及分子间相互作用。操纵单个核酸分子可以研究核酸结构的多样性，还可以研究核酸与蛋白质的相互作用。在该方向，张兴华以第一作者在《PNAS》上发表论文2篇、在《JACS》上发表论文1篇。核酸结构的多样性、RNA分子伴侣、转录异常中止导致的神经-肌肉退行性疾病、DNA同源重组修复是我们课题组的研究重点。

代表性论文：

1.Xinghua Zhang, Yuanyuan Qu, Hu Chen, Ioulia Rouzina, Shengli Zhang, Patrick S. Doyle*, and Jie Yan*. (2014). Interconversion between three overstretched DNA structures. J. Am. Chem. Soc. 136: 16073-16080.

2.Xinghua Zhang, Hu Chen, Shimin Le, Ioulia Rouzina, Patrick S. Doyle*, and Jie Yan*. (2013). Revealing the competition between peeled ssDNA, melting bubbles and S-DNA during DNA overstretching by single-molecule calorimetry. Proc. Natl. Acad. Sci. U.S.A. 110:3865-3870.

3.Xinghua Zhang, Hu Chen, Hongixa Fu, Patrick S. Doyle*, and Jie Yan*. (2012). Two distinct overstretched DNA structures revealed by single-molecule thermodynamics measurements. Proc. Natl. Acad. Sci. U.S.A. 109:8103-8108.

4.Shimin Le, Hu Chen Xinghua Zhang, Jin Chen, Neelakanteshwar Patil, Kalappa Muniyappad, and Jie Yan*. (2014). Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis. Nucleic. Acids. Res. 42: 11992-11999.

5.Hongxia Fu, Hu Chen, Xinghua Zhang, Yuanyuan Qu, John F. Marko and Jie Yan*.(2011) . Transition dynamics and selection of the distinct S-DNA and strand unpeeling modes of double helix overstretching. Nucleic. Acids. Res. 39:3473-348 .

6.Ximiao Hou, Xinghua Zhang, Kongji Wei, Chao Ji, Shuoxing Dou, Weichi Wang, Ming Li , Pengye Wang. (2009). Cisplatin induces loop structures and condensation of single DNA molecules. Nucleic. Acids. Res. 37: 1400-1410.

7.Xinghua Zhang, Bin Xiao, Ximiao Hou, Chunhua Xu, Pengye Wang and Ming Li*. (2009). Study of cisplatin-induced DNA compaction using single molecule magnetic-tweezers. Acta Physica Sinica. 58: 4301-4306.

8.Xinghua Zhang, Ximiao Hou, Chao Ji, Ming Li and Pengye Wang*. (2009). Spermidine-induced two dimensional DNA condensation on mica surface: a different pathway from the condensation in solution. Chinese Science Bulletin. 54:2425-2433

9.Bo Sun, Kongji Wei, Bo Zhang, Xinghua Zhang, ShuoXing Dou, Ming Li* and Xuguang Xi*. (2008). Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwinding. EMBO J. 27:3279-3287.

10.Wenbo Fu, Xiaoling Wang, Xinghua Zhang, Shiyong Ran, Jie Yan and Ming Li. (2006). Compaction dynamics of single DNA molecules under tension. J. Am. Chem. Soc. 128, 15040-15041