最新成果

首页  /  科学研究  /  最新成果  /  正文

Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles

作者:     点击:      时间:2018-06-01

Li, YX (Li, Yuxiu)[ 1 ] ; Wang, K (Wang, Kuai)[ 1 ] ; Ping, YY (Ping, Yuanyuan)[ 1 ] ; Wang, YF (Wang, Yifan)[ 1 ] ; Kong, WQ (Kong, Wangqing)[ 1 ]


ORGANIC LETTERS

卷: 20

期: 4

页: 921-924

DOI: 10.1021/acs.orglett.7b03713

出版年: FEB 16 2018

文献类型:Article


摘要

The first nickel-catalyzed domino Heck cyclization/Suzuki coupling reaction for the synthesis of 3,3-disubstituted oxindoles bearing quaternary all-carbon centers is reported. A wide range of electrophiles, such as aryl iodides, bromides, triflates, and chlorides, are all compatible with the reaction conditions. Moreover, cheap aryl esters, which undergo catalytic C-O bond cleavage, could also be employed as electrophiles. The approach shows good yields and broad scope, complementing a more practical and sustainable alternative to the conventional palladium-based analogues.

作者信息

通讯作者地址: Kong, WQ (通讯作者)

显示更多 Wuhan Univ, Inst Adv Studies, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China.

地址:

[ 1 ] Wuhan Univ, Inst Adv Studies, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China

电子邮件地址:wqkong@whu.edu.cn


原文PDF链接:

https://pubs.acs.org/doi/10.1021/acs.orglett.7b03713