最新成果

首页  /  科学研究  /  最新成果  /  正文

Metal-Free Direct Alkylation of Ketene Dithioacetals by Oxidative C(sp2)-H/C(sp3)-H Cross-Coupling

作者:     点击:      时间:2018-06-01

Wen, JW (Wen, Jiangwei)[ 1 ] ; Zhang, F (Zhang, Fan)[ 1 ] ; Shi, WY (Shi, Wenyan)[ 1 ] ; Lei, AW (Lei, Aiwen)[ 1,2 ]


CHEMISTRY-A EUROPEAN JOURNAL

卷: 23

期: 37

页: 8814-8817

DOI: 10.1002/chem.201701664

出版年: JUL 3 2017

文献类型:Article


摘要

The functionalization of internal olefins has been a challenging task in organic synthesis. This protocol provides an efficient and transition-metal-free direct oxidative C(sp(2))-H/C(sp(3))-H cross-coupling method to access tetrasubstituted olefins. The push-pull effect from the polarized olefin substrates accelerates the internal olefin C-H alkylation. Importantly, the mechanistic experimental results demonstrate that the alkanes C-H bond cleavage is the rate-determining step, and a radical pathway has been proposed for the alkylation reaction. Notably, the present protocol has excellent functional group tolerance and could be easily scaled up with good efficiency.

作者信息

通讯作者地址: Lei, AW (通讯作者)

显示更多 Wuhan Univ, Coll Chem & Mol Sci, IAS, Wuhan 430072, Hubei, Peoples R China.
通讯作者地址: Lei, AW (通讯作者)
显示更多 Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognizat & Funct, Inst Chem, Beijing 100190, Peoples R China.

地址:

[ 1 ] Wuhan Univ, Coll Chem & Mol Sci, IAS, Wuhan 430072, Hubei, Peoples R China
[ 2 ] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognizat & Funct, Inst Chem, Beijing 100190, Peoples R China

电子邮件地址:aiwenlei@whu.edu.cn


原文PDF链接:

https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201701664