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Symmetric cyanovinyl-pyridinium triphenylamine: a novel fluorescent switch-on probe for an antiparallel G-quadruplex†

Hai Lai,‡a Yijie Xiao,‡a Shengyong Yan,‡a Fangfang Tian,a Cheng Zhong,a Yi Liu,a Xiaocheng Weng*ab and Xiang Zhou*ab

 


In this study, we present a fluorescent switch-on probe based on a cyanovinyl-pyridiniumtriphenylamine (CPT) derivative that exhibited a 190-fold increase in fluorescence upon binding to G-quadruplexforming oligonucleotide 22AG. This probe showed specificity and selectivity towards an antiparallel G-quadruplex, indicating its promising
potential in G-quadruplex imaging.


 

Symmetric cyanovinyl-pyridinium triphenylamine: a novel fluorescent switch-on probe for an antiparallel G-quadruplex†
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