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Systematic Investigations of Different Cytosine Modifications on CpG Dinucleotide Sequences: The Effects on the B‑Z Transition

Shaoru Wang,† Yuelin Long,† Jiaqi Wang,† Yushu Ge,† Pu Guo,† Yi Liu,† Tian Tian,*,† and Xiang Zhou*,†,‡

 

†College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei 430072, P. R. China


‡State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, P. R. China

 


ABSTRACT: We have first demonstrated the distinctive effects of three newly reported epigenetic modifications, including 5hmC, 5fC, and 5caC, on B-Z transition of CpG dinucleotide DNAs. We have performed detailed assays and compared their effects. We further studied the regulation of B-Z transition of CpG dinucleotide dodecamers by alternating oxidation and alternating reduction.


 

Systematic Investigations of Different Cytosine Modifications on CpG Dinucleotide Sequences: The Effects on the B‑Z Transition
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