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External oxidant-free electrooxidative [3+2] annulation between phenol and indole derivatives

作者:admin     点击:138      时间:2018-05-31

Liu, K (Liu, Kun)[ 1 ] ; Tang, S (Tang, Shan)[ 1 ] ; Huang, PF (Huang, Pengfei)[ 1 ] ; Lei, AW (Lei, Aiwen)[ 1,2 ]


NATURE COMMUNICATIONS

卷: 8

文献号: 775

DOI: 10.1038/s41467-017-00873-1

出版年: OCT 3 2017

文献类型:Article


摘要

Intermolecular [3 + 2] annulation is one of the most straightforward approaches to construct five membered heterocycles. However, it generally requires the use of functionalized substrates. An ideal reaction approach is to achieve dehydrogenative [3 + 2] annulation under oxidant-free conditions. Here we show an electrooxidative [3 + 2] annulation between phenols and N-acetylindoles under undivided electrolytic conditions. Neither external chemical oxidants nor metal catalysts are required to facilitate the dehydrogenation processes. This reaction protocol provides an environmentally friendly way for the selective synthesis of benzofuroindolines. Various N-acetylindoles bearing different C-3 and C-2 substituents are suitable in this electrochemical transformation, furnishing corresponding benzofuroindolines in up to 99% yield.

作者信息

通讯作者地址: Lei, AW (通讯作者)

显示更多 Wuhan Univ, IAS, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.
通讯作者地址: Lei, AW (通讯作者)
显示更多 Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China.

地址:

[ 1 ] Wuhan Univ, IAS, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
[ 2 ] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China

电子邮件地址:aiwenlei@whu.edu.cn


原文PDF链接:

https://www.nature.com/articles/s41467-017-00873-1.pdf