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Electro-oxidative C(sp3)-H Amination of Azoles via Intermolecular Oxidative C(sp3)-H/N-H Cross-Coupling

作者:admin     点击:90      时间:2018-05-31

Wu, JW (Wu, Jiwei)[ 1 ] ; Zhou, Y (Zhou, Yi)[ 1 ] ; Zhou, YC (Zhou, Yuchen)[ 1 ] ; Chiang, CW (Chiang, Chien-Wei)[ 1 ] ; Lei, AW (Lei, Aiwen)[ 1,2 ]


ACS CATALYSIS

卷: 7

期: 12

页: 8320-8323

DOI: 10.1021/acscatal.7b03551

出版年: DEC 2017

文献类型:Article


摘要

A method for electrooxidative C(sp3)-H amination via intermolecular oxidative C(sp3)-H/N-H cross-coupling has been developed under metal- and oxidant-free conditions. The C(sp3)-H bonds adjacent to oxygen, nitrogen, and sulfur atoms could all react smoothly with various amines to give the corresponding products with moderate to good yields (30-93%). In addition, the C(sp3)-H bonds of benzylic and allylic are also tolerated in this reaction. A preliminary mechanistic study indicates that the C-H cleavage of tetrahydrofuran is probably not involved in the rate-determining step.

作者信息

通讯作者地址: Lei, AW (通讯作者)

显示更多 Wuhan Univ, IAS, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.
通讯作者地址: Lei, AW (通讯作者)
显示更多 Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China.

地址:

[ 1 ] Wuhan Univ, IAS, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
[ 2 ] Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China

电子邮件地址:aiwenlei@whu.edu.cn


原文PDF链接:

https://pubs.acs.org/doi/10.1021/acscatal.7b03551