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研究生指导教师介绍—孔望清

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孔望清

武汉大学高等研究院教授,博士生导师,

国家“青年千人计划”入选者(第十三批)

邮箱:wqkong@whu.edu.cn


研究方向

1)金属有机化学:过渡金属不对称催化

2)自由基化学:发展新的策略实现自由基反应的立体选择性控制

3)开展具有生物活性天然产物和药物分子的高效合成研究


导师介绍

工作经历

2017.04-        武汉大学高等研究院,教授

2014.10-2017.03   瑞士洛桑联邦理工大学 (EPFL),博士后,导师: Jieping Zhu

2011.09-2014.09   瑞士苏黎世大学 (UZH),博士后,导师: Cristina Nevado

教育经历

2006.09-2011.07  浙江大学,博士,导师:麻生明教授(中国科学院院士)

2002.09-2006.07  中国地质大学(武汉),学士

荣誉与奖励

2017年入选“青年千人”计划

诺华制药博士后奖学金(2012)

苏黎世大学博士后基金(2011)

浙江省优秀毕业生(2011)

宝钢优秀学生奖(2009)


研究成果介绍

  孔望清博士一直从事金属有机化学,自由基化学以及天然产物全合成等方面的研究。迄今为止,已经在化学领域国际知名杂志上发表论文25篇,其中第一作者和通讯作者论文19篇:包括化学类顶级期刊J. Am. Chem. Soc. (2篇),Angew. Chem. Int. Ed. (6篇);另有已授权专利4项;有6篇论文入选ESI “高被引论文”(top 1%);多篇论文还被专业评论杂志和学术网站如Synfacts, Chimia和Organic Chemistry Portal等刊登或作为亮点介绍。


独立后的研究工作:

1. Yuxiu Li, Kuai Wang, Yuanyuan Ping, Yifan Wang, and Wangqing Kong*.Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles. Org. Lett. 2018, 20, 921−924.

2. Kuai Wang,Wangqing Kong*. Recent advances in transition metal catalyzed radical transformations. Chin. J. Chem. 2018, 36, 247-256.

独立前的研究工作

3.Wangqing Kong, Qian Wang, Jieping Zhu*.Water as hydride source in palladium-catalyzed enantioselective reductive Heck reaction. Angew. Chem. Int. Ed.2017, 56, 3987-3991. (Chosen by the Editors as a “Hot Paper”)(Highlighted bySynfacts, 2017, 13, 495.)(Highly Cited Paper)

4. Wangqing Kong, Qian Wang, Jieping Zhu*.Switchable synthesis of diversely functionalized oxindoles enabled by migratory insertion of isocyanide to a transient σ-alkylpalladium(II) complex.Angew. Chem. Int. Ed.2016, 55, 9714-9718.

5. Wangqing Kong, Qian Wang, Jieping Zhu*. Palladium-catalyzed enantioselective domino heck/intermolecular C-H bond functionalization: Development and application to the synthesis of (+)-esermethole.J. Am. Chem. Soc.2015, 137, 16028-16031. (Highlighted bySynfacts, 2016, 3, 274.)

6. Wangqing Kong, Noelia Fuentes, Andres García-Domínguez, Estíbaliz Merino, Cristina Nevado*. Stereoselective synthesis of highly functionalized indanes and dibenzocycloheptadienes via complex radical cascades. Angew. Chem. Int. Ed.2015, 54, 2487-2491.

7. Noelia Fuentes, Wangqing Kong, Luis Fernández-Sánchez, Estíbaliz Merino, Cristina Nevado*. Cyclization cascades via N-amidyl radicals toward highly functionalized heterocyclic scaffolds. J. Am. Chem. Soc. 2015, 137, 964-973. (Highly Cited Paper)

8. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Arylphosphonylation and arylazidation of activated alkenes.Angew. Chem. Int. Ed. 2014, 53, 5078-5082.(Chosen by the Editors as a “Hot Paper”)(Highly Cited Paper)

9. Wangqing Kong, Maria Casimiro, Noelia Fuentes, Estíbaliz Merino, Cristina Nevado*.Metal-free aryltrifluoromethylation of activated alkenes. Angew. Chem. Int. Ed. 2013, 52, 13086-13090. (Highly Cited Paper)

10. Wangqing Kong, Maria Casimiro, Estibaliz Merino, Cristina Nevado*. Copper-catalyzed 1-pot trifluoromethylation/arylmigration/desulfonylation and Csp2-N bond formation of conjugated tosyl amides. J. Am. Chem. Soc. 2013, 135, 14480-14483. (Highly Cited Paper)

11. Wangqing Kong,Pascal Feige, Teresa de Haro, Cristina Nevado*. Regio- and enantioselective aminofluorination of alkenes.Angew. Chem. Int. Ed. 2013, 52, 2469-2473. (Highlighted bySynfacts2013, 9, 371and Organic Chemistry Portal2014, 3, 17.)(Highly Cited Paper)

12. Wangqing Kong, Youai Qiu,Xue Zhang, Chunling Fu,Shengming Ma*.Exclusive 1,2-aryl shift in Platinum(II) chloride-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols. Adv. Synth. Catal. 2012, 354, 2339-2347.

13. Wangqing Kong, Chunling Fu, Shengming Ma*. General Au-catalyzed benzannulation towards naturally occurring carbazole alkaloids from methoxypropadiene. Chem. Eur. J. 2011, 17, 13134-13137.

14. Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of carbazoles from PtCl2-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols.Chem. Commun. 2009, 4572–4574.

15. Wangqing Kong, Jie Cui, Yihua Yu, Guofei Chen, Chunling Fu, Shengming Ma*. PtCl4-catalyzed cyclization reaction of β-allenols in the presence of indole.Org. Lett.2009, 11, 1213-1216.

16.Wangqing Kong, Chunling Fu, Shengming Ma*.Efficient synthesis of carbazoles via PtCl2-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: scope and mechanism.Org. Biomol. Chem. 2012, 10, 2164-2173.

17. Wangqing Kong, Binjie Guo, Chunling Fu, Shengming Ma*. An efficient approach to 2-bromoalken-3-ols by regioselective bromohydroxylation reaction of simple allenes with NBS. Eur. J. Org. Chem.2011, 2278-2285.

18.Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient synthesis of polysubstituted naphthalene derivatives by gold-catalyzed cyclization of  1-arylalka-2,3-dienyl acetates. Eur. J. Org. Chem.2010,6545-6555.

19.Wangqing Kong, Chunling Fu, Shengming Ma*. Indium and zinc-mediated Barbier-type addition reaction of 2,3-allenals with allyl bromide: an efficient synthesis of 1,5,6-alkatrien-4-ols. Org. Biomol. Chem.2008, 6, 4587–4592.

20.Youai Qiu, Wangqing Kong, Chunling Fu, Shengming Ma*. Carbazoles via AuCl3-catalyzed cyclization of 1-(indol-2-yl)-3-alkyn-1-ols. Org. Lett. 2012, 14, 6198-6201.

21.Jing Li, Wangqing Kong, Chunling Fu, Shengming Ma*. An efficient CuCN-catalyzed synthesis of optically active 2,3-allenols from optically active 1-substituted 4-chloro-2-butyn-1-ols.J. Org. Chem. 2009, 74, 5104–5106.

22.Jing Li, Wangqing Kong, Yihua Yu, Chunling Fu, Shengming Ma*. Studies on electrophilic reaction of tertiary 2,3-allenols with NBS in H2O or aqueous MeCN: an efficient selective Synthesis of 2-bromoallylic ketones, 1,2-allenyl ketones, or 3-bromo-2,5-dihydrofurans.J. Org. Chem. 2009, 74, 8733–8738.

23. Xuefeng Jiang, Wangqing Kong, Jie Chen, Shengming Ma*. Intermolecular sequential [4+2]-cycloaddition–aromatization reaction of aryl-substituted allenes with DMAD affording phenanthrene and naphthalene derivatives.Org. Biomol. Chem. 2008, 6, 3606–3610.

24. Youai Qiu, Dengke Ma, Wangqing Kong, Chunling Fu,  Shengming Ma*. Regiocontrolled 1,2-migration in cyclization of 1-(indol-2-yl)-3-alkyn-1-ols: (Ph3P)Au+ vs. PtCl4. Org. Chem. Front. 2014, 1, 62-67.

25. Wangqing Kong, Estíbaliz Merino, Cristina Nevado*. Divergent reaction mechanism in the aminofluorination of alkenes. CHIMIA International Journal for Chemistry, 2014, 68, 430-435.


专利:

1.一种合成咔唑类化合物的方法,专利号:ZL 200910099482.X

2.一种合成咔唑类生物碱 Siamenol 的方法,专利号:ZL 201110283659.9

3.一种合成天然咔唑类生物碱的制备方法,专利号:ZL 201110283147.2

4.一种合成咔唑类化合物的方法,专利号:ZL 201210516430.X


课题组招贤纳才

博士后

  薪酬待遇:工资及福利待遇根据武汉大学相关规定从优考虑(五险一金,提供住房,解决户口和子女入学等问题);并根据工作业绩额外发放津贴(预计年薪25-30万元,具体薪资待遇面议);可作为负责人申请博后基金、国家青年基金、和湖北省相关基金。博士后期间特别优秀者可协助申请武汉大学正式教师(非独立成组)。

职位要求:

1)有机化学博士,有写作和发表英文科技论文经历。

2)有团队精神,工作踏实,有责任感,易沟通。

3)有金属有机化学(特别是过渡金属不对称催化)或自由基化学研究经历者优先考虑。

请发送个人简历、主要研究成果等相关资料到:wqkong@whu.edu.cn

研究助理2-3名

薪酬待遇:将提供具有竞争力的薪酬待遇,并根据工作业绩额外发放津贴,可优先报考硕士或者博士研究生。

职位要求:

1)本科或硕士学位,化学相关专业,熟悉常规有机化学实验技术和操作。

2)工作踏实,有责任感,具有良好的沟通能力和合作精神。

3)英语良好,能独立阅读英文文献。

请发送个人简历及其他能证明本人能力的相关资料到:wqkong@whu.edu.cn

研究生

  欢迎全国的优秀学子报考本小组的博士或硕士研究生。要求专业基础扎实,工作踏实,有团队精神,具有良好的沟通能力。我们将提供具有竞争力的待遇,并根据工作业绩额外发放津贴。有意者请直接邮件联系wqkong@whu.edu.cn





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